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Date: Thu, 9 Dec 2010 18:19:36 -0800
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: Randy Norman <rnormanusa**At_Symbol_Here**YAHOO.COM>
Subject: Re: Chemical Safety and Lab Animals
In-Reply-To: <785929.34918.qm**At_Symbol_Here**web121604.mail.ne1.yahoo.com>
--0-1725991586-1291947576=:42338
To follow on from my earlier message. We're set up with a set of standard p
recautions in our Tox animal facility=A0that are very strict and based on t
he assumption that little is known regarding the toxicological properties o
f the test articles we study. Our precautions are based on the NTP contract
lab H&S minimum requirements and the considerations and recommendations th
at one can read about in Dr Walters' book.
=A0
I do perform a review of available information concerning every substance b
efore it is placed on test,=A0including MSDS if available=A0and usually=A0s
upplemented by a literature search. However most of the time that review is
more geared towards determining if enough tox data is known to allow us to
relax our precautions slightly.
=A0
I am=A0currently a one-man EHS Department and the longest standing voting m
ember of our IACUC, having served on it=A0over 22 years, including several
years that I served as IACUC Chair. So communication and coordination=A0bet
ween EHS and=A0our=A0IACUC=A0are easy for us.=A0I see every IACUC protocol
as well as performing my own review of every incoming test substance and ro
utinely provide the other IACUC members with information concerning those r
are studies that may require unusual precautions. My review usually begins
before the test article even arrives, as the Project Manager sends me the M
SDS or test article characterization. They will also consult me well in adv
ance of a study when a potential test article has especially unusual proper
ties that may prove problematic. For example we have done tox studies in an
imals of a small number of explosive materials, and each of those studies r
equired special precautions and close coordination between EHS and the lab
staff.
=A0
I know that some academic institutions have merged their IACUC and EHS appr
oval processes using a variety of tactics. So there are several ways to ass
ure that=A0the necessary revews are accomplished, and even though I obvious
ly have it easy, it's definitely not an impossible task.=A0
=A0
Randal O. Norman
--- On Thu, 12/9/10, Randy Norman wrote:
--0-1725991586-1291947576=:42338
To follow on from my earlier message. We
're set up with a set of standard precautions in our Tox animal facility that are very strict and based on the assumption that little is known re
garding the toxicological properties of the test articles we study. Our pre
cautions are based on the NTP contract lab H&S minimum requirements and
the considerations and recommendations that one can read about in Dr Walte
rs' book.
I do perform a review of available information concerning every substa
nce before it is placed on test, including MSDS if available and
usually supplemented by a literature search. However most of the time
that review is more geared towards determining if enough tox data is known
to allow us to relax our precautions slightly.
I am currently a one-man EHS Department and the longest standing
voting member of our IACUC, having served on it over 22 years, includi
ng several years that I served as IACUC Chair. So communication and coordin
ation between EHS and our IACUC are easy for us. I
see every IACUC protocol as well as performing my own review of every inco
ming test substance and routinely provide the other IACUC members with info
rmation concerning those rare studies that may require unusual precautions.
My review usually begins before the test article even arrives, as the Proj
ect Manager sends me the MSDS or test article characterization. They will a
lso consult me well in advance of a study when a potential test article has
especially unusual properties that may prove problematic. For example we h
ave done tox studies in animals of a small number of explosive materials, a
nd each of those studies required special precautions and close
coordination between EHS and the lab staff.
I know that some academic institutions have merged their IACUC and EHS
approval processes using a variety of tactics. So there are several ways t
o assure that the necessary revews are accomplished, and even though I
obviously have it easy, it's definitely not an impossible task.
Randal O. Norman
--- On Thu, 12/9/10, Randy Norman <rn
ormanusa**At_Symbol_Here**YAHOO.COM> wrote: |
--0-1725991586-1291947576=:42338--
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