Jeff,

 

Try these links, they are mostly classic papers from process safety literature.  These papers primarily focus on thermal runaway and pressure generation that can lead to catastrophic equipment failure.  They don’t address issues of occupational exposure to chemicals.

 

Recommended Literature for Process Safety

 

Note:  Recommend documents 2, 3, and 5 as introductory literature

 

Thermal Risk Evaluation

 

1.       Chemical Rxn Engineering Safety Gygax 1988 - http://ac.els-cdn.com/0009250988870404/1-s2.0-0009250988870404-main.pdf?_tid=ce637eea-8906-11e7-8044-00000aacb360&acdnat=1503604978_df54e7b9c5c122afb38c6b5d06dc6e19

 

2.       Townsend, Thermal hazard evaluation by an accelerating rate calorimeter; https://www.sciencedirect.com/science/article/pii/0040603180850015

 

3.       Stoessel review in OPRD_1997: http://pubs.acs.org/doi/pdfplus/10.1021/op970016i

 

4.       Stoessel Planning protection measures against runaway reactions using criticality classes 2009: http://ac.els-cdn.com/S0957582008001134/1-s2.0-S0957582008001134-main.pdf?_tid=8414813e-8908-11e7-aa92-00000aacb360&acdnat=1503605712_0394a33b0b60648ce109bfb84b79f088

 

5.       Selection of the Proper Calorimetric Test Strategy in Reactive Chemicals Hazard Evaluation, Frurip (Dow Chemical) - OPRD 2008 -  http://pubs.acs.org/doi/pdf/10.1021/op800121x

 

 

Pressure Relief Evaluation

 

6.       Fauske Monogram 1984 Generalized Vent Sizing Monogram for Runaway Chemical Reactions: https://cdn2.hubspot.net/hubfs/232514/Fauske-2017/PDF/GeneralizedVentSizingNomogramforRunnawayChemicalReactions_0.pdf?t=1503591010230

 

7.       Comparison of pressure-relief calculation methods;  https://cdn2.hubspot.net/hubfs/232514/Fauske-2017/PDF/IntroducingPrEVent-PracticalEmergencyVentSizingSoftware.pdf?t=1495047142584  - list of original references for models and data

 

Training Sources (2017)

A.       AIChE DIERS training http://www.iomosaic.com/diersweb/courses.aspx

 

B.       CCPS https://www.aiche.org/ccps; https://www.aiche.org/academy/

 

C.       Dekra Course Calendar:  https://www.dekra-process-safety.com/process-safety-academy

 

D.    Fauske Training https://www.fauske.com/training

 

E.     Mettler Toledo Training course list (live & web) https://www.mt.com/hk/en/home/perm-lp/product-organizations/ana/ta-etraining.html

 

F.     Iomosaic Training - http://www.iomosaic.com/training/available-courses

 

 

Best, chuck

 

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Hello

I’m currently working on a safety talk about RAMP and decided to include a section on “RAMPing up Reactions”

It was discussed at ACS that scaling up reactions is a under-stated danger in many chemistry laboratories.

 

Does anyone have any suggestion for articles that talks about or quantifies the risks of increasing the yield in chemical reactions?

 

For example: https://ac.els-cdn.com/S1871553213006178/1-s2.0-S1871553213006178-main.pdf?_tid=672cf49d-0170-4ff1-8b06-85bc88bda807&acdnat=1537887055_4baf3ea46cec9ef7b4cb51c2aba76bf8 I found very informative and it would be great to find more sources.

 

Thanks

 

Jeffrey R. Cogswell, Ph.D.

Chemical Inventory and Laboratory Resource Center Technician, EHS

37 Dewey Field Road, HB 6216

Hanover, New Hampshire 03755

http://www.dartmouth.edu/~ehs/

 

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